ISREC-SCCL Symposium 2023: Horizons of Cancer Biology and Precision Oncology

Chair: Douglas Hanahan, ISREC-AGORA, Lausanne

Leila Akkari - Amsterdam, Netherlands

Dissecting and Rewiring Macrophage Heterogeneity in the Cancer Ecosystem

Short talk:   Charly Jehanno (Bentires-Alj group) - Basel, Switzerland

NNMT sustains a core epigenetic program that promotes metastatic colonization in breast cancer

Nicola Aceto - Zürich, Switzerland

Circulating tumor cells

Maria Rescigno - Milan, Italy

The microbiota in enhancing cancer treatment efficacy

Michal Bassani-Sternberg - Lausanne, Switzerland

The immunopeptidome landscape associated with T cell infiltration, inflammation and immune-editing in lung cancer

Chair: Michele De Palma, ISREC-EPFL, Lausanne

Eduard Batlle - Barcelona, Spain

Stem cells, immune evasion and metastasis in colorectal cancer

Short talk:   Kathleen Luckett (Ganesh group) - New York, USA

Mapping the Coevolution of Tumor and Immune Cells in Metastatic Colorectal Cancer

Short talk:   Ruxandra-Andreea Lambuta (Prof Elisa Oricchio group) - Lausanne, Switzerland

Whole-genome doubling drives oncogenic loss of chromatin segregation

Alberto Bardelli - Turin, Italy

Tracking and targeting colorectal cancer evolution

incl. Coffee Break

Chair: Johanna Joyce, UNIL, Lausanne

Camilla Jandus - Geneva, Switzerland

Nerve Growth Factor (NGF) drives ILC2 pro-tumoral function in bladder cancer

Short talk:   Julien Racle (Gfeller group) - Lausanne, Switzerland

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Diletta Di Mitri - Rozzano, Italy

Autophagy inhibition hinders NK cell function in cancer

Yvonne Chen - Los Angeles, USA

Engineering Next-Generation T Cells for Cancer Immunotherapy

Chair: David Gfeller, UNIL, Lausanne

Nuria Lopez-Bigas - Barcelona, Spain

Tumor genomes shed light into somatic mutational processes and cancer vulnerabilities

Short talk:   Triparna Sen - New York, USA

Dissecting the transcriptional and epigenetic landscape of lineage plasticity in lung cancer

- Sponsored by Lunaphore -
Giovanni Ciriello - Lausanne, Switzerland

Non-genetic routes of lung cancer evolution

Wouter Karthaus - Lausanne, Switzerland

Treatment induced lineage plasticity and drug resistance in prostate cancer

Agnel Sfeir - New York, USA

MMEJ in Mitosis: A Last-Ditch Effort to Safeguard Genomes

Chair: Caroline Arber, UNIL, Lausanne

Johanna Joyce - Lausanne, Switzerland

Exploring and Therapeutically Exploiting the Tumor Microenvironment

Short talk:   Jose M. Adrover (Mikala Egeblad group) - Cold Spring Harbor, USA

A vascular-restricted, tumor-induced neutrophil population drives vascular occlusion, pleomorphic necrosis, and metastasis

Short talk:   Máté Kiss (Pittet group) - Lausanne, Switzerland

A neutrophil response linked to tumor control in immunotherapy

Ilaria Malanchi - London, United Kingdom

The Piecemeal Model of metastatic dormancy and reactivation

incl. Coffee Break

Saar Gill - Philadelphia, USA

Genetically engineered hematopoietic stem cell transplantation for the treatment of leukemia

Short talk:   Samantha Mahfoud (Petrova group) - Lausanne, Switzerland

A collaborative stromal niche orchestrates the initiation of tumor-associated tertiary lymphoid structures

Michele De Palma - Lausanne, Switzerland

Antigen-agnostic dendritic cell therapy

Chair: Tatiana Petrova, UNIL, Lausanne

Joerg Huelsken - Lausanne, Switzerland

Metastasis initiating cells are induced by immunotherapy and rely on specific metabolic mechanisms

Short talk:   Costanza Borrelli (Andreas Moor group) - Basel, Switzerland

​​​​In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis

Sebastian Waszak - Lausanne, Switzerland

Parent-of-origin-dependent divergent somatic evolution in medulloblastoma

Christian Frezza - Cologne, Germany

Fumarate hydratase loss as a paradigm of oncometabolism

Sarah-Maria Fendt - Leuven, Belgium

Nutrient dependencies of metastasis formation

Chair: George Coukos, CHUV, Lausanne

Denis Migliorini - Geneva, Switzerland

Novel combinatorial strategies with engineered immune cells for malignant glioma

Short talk:   Tancredi Massimo Pentimalli (Rajewsky group) - Berlin, Germany

3D molecular reconstruction of a human tumor at single-cell resolution reveals invasion dynamics and predicts mechanism-based, personalized therapeutic targets

Short talk:   Melanie Tichet (Hanahan group) - Lausanne, Switzerland

Reprogramming immunosuppressive tumor-associated macrophages potentiates standard-of-care therapy in melanoma

incl. Coffee Break

- Keynote Lecture sponsored by Roche -
Jennifer Wargo - Houston, USA

Targeting the microbiome to promote health and end cancer

Closing banquet on the lake steamer